Manaus → Miami (19 nights)

The beating heart of the Brazilian rainforest. This bustling frontier town emanates a verdigris grandeur, a throwback to the rubber boom gone by, illustrated best by the Belle Epoque opera house, with its marble halls and 198 Murano glass chandeliers. Drift away to the Philharmonic strains of Verdi or Mozart under frescoed ceilings in the midst of the steamy jungle. Outside, the inky Rio Negro meets but doesn’t merge with the more muddied Rio Solimoes, and pink dolphins, manatees and river otters ply the wide and winding waterways, the banks and jungle trails scattered with waterfalls, wild orchids, spider monkeys and jaguars.

Tap into Amazonian rhythms in Parintins, where indigenous life and Brazil’s carnival culture entwine. Explore winding tributaries by riverboat and fish for piranha in secluded coves, or trek to villages swathed in jungle. Carnival fever burns year-round as artisans tirelessly toil over fantastical floats and elaborate dresses for the annual Boi-Bumbá Festival, here in the beating heart of the Amazon.

The crystal-clear waters and fine white sands at this secluded Amazon beach town invite comparisons with the Caribbean. Discover this gem of a village, which leads to Love Island, Green Lake, and water lilies spanning up to 3m (10ft) in diameter. From this laid-back beguiling base, we might witness the peculiar Meeting of the Waters, as the mighty Amazon and clearer waters of the Rio Tapajos meet but don’t converge, continuing to flow instead side by side. Delve deep into the dense Tapajos National Forest, seeking jungle cats, giant armadillos, vibrant parrots and protected white-bellied spider monkeys.

Please note that the call to Macapá is a technical call required for clearance by the Brazilian authorities. Guests will not be able to disembark during this time. The clearance process includes a safety inspection, health inspection, and immigration formalities. Depending on the complexity, this may take several hours.

At first glance, Devil’s Island looks like paradise. Dotted with towering palm trees and surrounded by sparkling waters, this idyllic isle was once where Emperor Napoleon III imprisoned his enemies. Immortalised in “Papillon,” the hauntingly beautiful ruins hold secrets one shudders to imagine. Discover the mysteries for yourself on footpaths that ring the island and lead to ghostly churches built by prisoners. All that remains is the pristine jungle teeming with peacocks and monkeys, brilliant bougainvillea and butterflies. As you leave Devil’s Island, you realise you will forever be prisoner to its beauty.

Summon your inner Robinson Crusoe on remote Bequia. Secret lagoons. Castaway picnics. Warm waters in shades of blue that beg to be snorkelled through. Stake your flag in the sweet Bequia breeze just as the Union Jack did for almost 200 years. Usher in deep tranquillity on lovely Princess Margaret Beach. Ascend Mount Peggy with sunny views of St. Vincent. Stoll Belmont Boardwalk to Margret Beach for hand-whittled mahogany boat models then prowl the concrete catwalk that runs along Port Elizabeth for home-churned nutmeg ice cream. Support a sterling turtle sanctuary protecting the rare hawksbill or ferry to nearby Mustique, the favourite holiday romp for Prince William and Kate Middleton.

Gently breeze into the vibrant capital of Barbados. Steeped in fascinating history, with architecture to match, uncover the wonderfully laid-back West Indian ambiance. Embrace the slow Bajan rhythm of this welcoming island; surf, snorkel and try spotting turtles in balmy azure waters. Explore subterranean Harrison’s Cave, Jacobean St Nicholas Abbey and zipline high above bountiful tropical flora. Then return to restore on pastel pink sands at palm-studded beaches, where you’ll discover cocktail hour is endless, and measures of rum are copious.

Wind your way through the romantic island of St Lucia. Hike up the majestic UNESCO-listed Pitons, wallow in a volcanic mud bath, lounge on black sand beaches, explore botanical gardens and venture into a tropical jungle scattered with banana, coconut and mango plantations. Choose between calm Caribbean or choppy Atlantic seas to skim through waters by catamaran, private boat or kayak. Refresh beneath a waterfall, watch gliding whales and enjoy freshly caught mahi mahi with local Piton beer. Or just relax into an inner glow of serenity as you unwind in this tranquil tropical isle.

Mingle amongst other discerning guests on this French isle that exudes relaxed glamour. Wander along secluded beaches, harbourside Creole huts, drop into bohemian bars and snorkel gently through warm turquoise waters. Visit La Tourmente, the peaceful salt ponds and admire uninterrupted views on a local boat trip. And as you sip your second (or third) glass of champagne to the lull of the gentle waves, it might be time to learn the French for "paradise found".

Formed by volcanoes, St Kitts fertile soil is so rich it turns monkeys green. Trek through miles of rainforest amongst colourful wildlife to conquer the highest peak of Mount Liamuiga so you can peer into the mile-wide crater, or bravely descend to sniff the sulphur. Experience a train ride, sailing trip, cooking class, sky safari zip-line, or creative batik fabric workshops. Visit sugarcane plantations, the Narrows between St Kitts and Nevis and the UNESCO Brimstone Hill Fortress for spectacular views of neighbouring islands. You’ll find this special island small in size yet tall in standing, as well as big on charm.

Explore the oldest US city for a dose of Caribbean history, slice of Spanish culture and twist of American dream. Roam historic Old San Juan alleyways to glimpse centuries-old forts and colourful colonial buildings. Learn how to move, as locals sashay out the salsa to rhythmic reggae beats. Shop the boho streets or glamorous boutiques for artisan goods, decadent designers and hand-rolled cigars. Experience world-class surfing, explore a tropical rainforest, attend a private rum cocktail tasting and polish off empanadas. Then retire to one of the beautiful beaches to soak up crystal clear waters and, perhaps, one last rum cocktail.

An adrenaline rush awaits. Swim with stingrays. Zip-line through lush forests. Walk across a gorge on a scenic suspension bridge. Sip excellent aged rums. Taste the island with a chef. Or stroll St. John's old town to tour cottages laden with cheerful fretwork. Explore British forts atop Shirley Heights and Goat Hill. Then rest and rejuvenate at one of the snow-white beaches.

Restore in blissfully quiet yet sophisticated laid-back island life. Roam amongst wildlife, learn fascinating insights into Anguilla's quirky history and gently wander to the limestone cavern of Katouche cave. Embark on a guided quad bike tour for a glimpse of island life and sail over electric blue seas to reach remote paradise at private Little Bay, where jagged cliffs flank pristine sands. Casually kayak or paddle board through warm breezes and calm waters to secluded coves and indulge in refreshing cocktails with butter-soaked grilled lobster at enticing beach bars, with toes submerged in the softest, whitest and finest sand.

Slip into a tranquil, tropical paradise of sparkling waters, coral reefs and powder white beaches. Switch off and slowly shop, swim, snorkel and sip within the peace of sand, sea and sky. Sink into a beachside boulder-forming pool at The Baths, admire spectacular villas scattered on the Great Mountain, sit back on a safari bus ride or sunbathe aboard a catamaran. Prepare to be mesmerised by this softly lit, sun-drenched heaven.

Take your time, for happy hour is infinite here. Embrace the radiant warmth as you absorb the island’s history within sparkling turquoise seas that join sapphire skies. Discover the iconic salt flats, visit old-world villages, taste conch and look out from the lighthouse. Snorkel and dive through calm crystal-clear waters and revel at a rum punch party aboard a catamaran. Or perhaps you’d prefer a little snooze beneath some bougainvillea shade – a compliment to the slower, more measured pace of life.

Welcome to Miami and the sweep of South Beach - backdrop to every iconic Miami movie, and forefront of Latin American culture. Stroll through pastel-hued geometric buildings in the art deco district, to graffiti mural masterpieces at Wynwood Walls. Watch Latino life unfold in Little Havana - the heartbeat of this great city - where walk-up windows sell café cortadito, sweet sugarcane juice, hatuey beer and guava ice-cream. Watch passionate locals discuss politics, play dominoes and smoke cigars. Shimmy at a salsa class, shop designer boutiques and race marlin and sharks by speedboat. Then slow your pace to uncover rare and endangered species at the Everglades National Park outdoor oasis. You’ll find the Miami dream is real – and it’s not just Cuban heels that will give you a spring in your step.