Fusina (Venice) → Piraeus (Athens) (7 nights)

Delve into ancient palaces, century-old galleries, and modern-day exhibits as you whirl through Venice. Walk through masterpieces, catch an opera, gaze at medieval buildings, blow Murano glass and drift down the Grand Canal by gondola to visit churches, convents and campi “squares” that vary in spirit and scale. Cross hump-backed bridges, reach teeming Piazza San Marco’s Basilica and Doge’s Palace, or duck down passages to escape reality. From palazzos to perfumeries and the must-see Bridge of Sighs, you’re only moments from a place of beauty in this liquid-gold city of treasures.

Squeezed onto a tiny yin-yang island of terracotta roofs and green gardens, pretty little Rovinj is the belle of Croatia. Pastel-coloured houses teeter over the crystal-clear waters of the Adriatic and climb up the hillside to the iconic bell tower of St. Euphemia Church, a permanent reminder of the city’s Venetian roots. Delve into the maze of narrow streets lost in time, galleries and museums overhung with wooden balconies and Italianate shutters. Circle the city in a flat-bottomed batana fishing boat or kayak around the pine-forested shores of outlying islands, forage for local wines and honey in timeless markets and taste the flavours of the Istrian Peninsula in waterfront cafes.

Marvel at this chic walled city paved with a wealth of aristocratic palazzi, ancient forts and epic Adriatic views. Enter grand Pile Gate to lose yourself in intricate alleys, stage-set squares, museums and baroque churches. Ease out of town to kayak around sturdy ramparts, taste Dalmatian wines in the Konavle countryside, and visit archaic Cavtat and history-packed Mostar. Escape the crowds to cacti-clad Lokrum for a spot of yoga and botanical walking, or join in to graze at trendy restaurants on the rocks. It’s no wonder the glitterati flock to the strength of this charming and inspiring medieval Dalmatian marvel.

Brindisi's historic heart is rich in multi-layered monuments and finds from the days of Spartacus. Farther afield, the gleaming white villages of Ostuni or the slightly smaller and possibly even quainter, Cisternino. Head east to the Baroque Town of Lecce or west to witness the traditional conical huts (trulli) in and around World Heritage Site, Alberobello. Lecce, or 'Florence of the South', is rife with art, history and culture. If peace and quiet appeal, waft through rural Torre Guaceto's nature reserve and empty beaches or take a jaunt on the Adriatic to Polignano's sea caves. Puglia's 'little ear' pasta and squid's ink gnocchi are must-try delicacies, and with 60 million olive trees, they are rich in liquid gold. Brindisi serves up the best of Puglia.

Experience the vibrant, cosmopolitan charm of Kefalonia. Wind through the crescent-shaped Venetian architecture surrounded by the sounds of classical music. Head to pebbled coves, bijoux boutiques and gelato caverns, or snorkel, dive, kayak and hike through nature in all its Mediterranean glory, surrounded by the scents of pine, lavender and cedar. Slip across to the secluded beaches of Ithaca – home to Homer’s ‘The Odyssey’ and vibrant underwater reefs. And relax at lavish seafood eateries and sip robola as you mingle amid refined, elegant guests.

This horseshoe-shaped island at the outer edge of the Cyclades is where Venus de Milo was unearthed in 1820 – the unexpected bounty of a local farmer that now sits in the Louvre and remains one of the world’s greatest antiquities. Visitors here might find the ruins of the Hellenistic marble amphitheatre and 1st-century catacombs just as compelling, whilst others will be drawn to the island’s wild and colourful landscape, from hot springs, mines and volcanoes to rocky hillsides coloured russet, pink and orange. Of the 78 beaches, Sarakiniko’s white rocks sculpted by wind and waves lend it a lunar quality, whilst others proffer volcanic sands, sea caves and rock arches, each home to crystalline waters. Climb to the castle ruins in the hilltop capital Plaka for sunset views.

Athenians don’t live in the past. Ahead of its time, Athens exudes glamour and a sense of possibility - housing galleries, gelaterias, bijoux boutiques alongside a plethora of museums. And you can’t help but marvel at the archaeological wonders of the Acropolis and the Parthenon. Stroll through vibrant streets and markets, dance at buzzing bouzoukia, sing along in tavernas. At night, head to the harbour, where dimly lit bars serve the local ice cold beer. And, as you inhale the salty air and watch Greek fishing boats peacefully depart for their catch, reflect on this ancient city's progressive attitude.